According to the narrative, "the last of the Holston family" - one of the three first (white) families in Yoknapatawpha - died "before the end of the last century," i.e. sometime before 1900 (70). This story does not connect the family to the Holston House, the Jefferson hotel that survives into the 20th century.
The road that Stevens drives along to get from Jefferson to the site of the inquest on Lonnie Grinnup's body is described as "eight miles" long (70). Because Lonnie lives "almost in the exact center of the thousand and more acres his ancestors had once owned" (71), and the first of these ancestors was a "Grenier" (the original Old Frenchman, 70), we assume the road leads out of Jefferson to the southeast, where the hamlet of Frenchman's Bend sits near the river.
Long gone by the time of the story, the "Chickasaw Agency post" was the first white settlement in Yoknapatawpha, the origin of Jefferson (70). It was already there "a hundred years" ago - i.e. in the 1830s - when the first white pioneers arrived on the scene and "bought land in the Indian patent" (70).